Polyinosinic acid decreases sequestration and improves systemic therapy of measles virus

Off target binding or vector sequestration can significantly limit the efficiency of systemic virotherapy. We report here that systemically administered oncolytic measles virus (MV) was rapidly sequestered by the mononuclear phagocytic system (MPS) of the liver and spleen in measles receptor CD46-po...

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Detalles Bibliográficos
Autores principales: Liu, Yu-Ping, Tong, Caili, Dispenzieri, Angela, Federspiel, Mark J., Russell, Stephen J., Peng, Kah-Whye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288770/
https://www.ncbi.nlm.nih.gov/pubmed/22116376
http://dx.doi.org/10.1038/cgt.2011.82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288770/
https://www.ncbi.nlm.nih.gov/pubmed/22116376
http://dx.doi.org/10.1038/cgt.2011.82

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