Intra- and Inter-Subunit Disulfide Bond Formation Is Nonessential in Adeno-Associated Viral Capsids

The capsid proteins of adeno-associated viruses (AAV) have five conserved cysteine residues. Structural analysis of AAV serotype 2 reveals that Cys289 and Cys361 are located adjacent to each other within each monomer, while Cys230 and Cys394 are located on opposite edges of each subunit and juxtapos...

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Detalles Bibliográficos
Autores principales: Pulicherla, Nagesh, Kota, Pradeep, Dokholyan, Nikolay V., Asokan, Aravind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289628/
https://www.ncbi.nlm.nih.gov/pubmed/22389684
http://dx.doi.org/10.1371/journal.pone.0032163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289628/
https://www.ncbi.nlm.nih.gov/pubmed/22389684
http://dx.doi.org/10.1371/journal.pone.0032163

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