A Catalytic Mechanism for Cysteine N-Terminal Nucleophile Hydrolases, as Revealed by Free Energy Simulations

The N-terminal nucleophile (Ntn) hydrolases are a superfamily of enzymes specialized in the hydrolytic cleavage of amide bonds. Even though several members of this family are emerging as innovative drug targets for cancer, inflammation, and pain, the processes through which they catalyze amide hydro...

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Detalles Bibliográficos
Autores principales: Lodola, Alessio, Branduardi, Davide, De Vivo, Marco, Capoferri, Luigi, Mor, Marco, Piomelli, Daniele, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289653/
https://www.ncbi.nlm.nih.gov/pubmed/22389698
http://dx.doi.org/10.1371/journal.pone.0032397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289653/
https://www.ncbi.nlm.nih.gov/pubmed/22389698
http://dx.doi.org/10.1371/journal.pone.0032397

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