Determinants of Reactivity and Selectivity in Soluble Epoxide Hydrolase from Quantum Mechanics/Molecular Mechanics Modeling

[Image: see text] Soluble epoxide hydrolase (sEH) is an enzyme involved in drug metabolism that catalyzes the hydrolysis of epoxides to form their corresponding diols. sEH has a broad substrate range and shows high regio- and enantioselectivity for nucleophilic ring opening by Asp333. Epoxide hydrol...

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Detalles Bibliográficos
Autores principales: Lonsdale, Richard, Hoyle, Simon, Grey, Daniel T., Ridder, Lars, Mulholland, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290109/
https://www.ncbi.nlm.nih.gov/pubmed/22280021
http://dx.doi.org/10.1021/bi201722j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290109/
https://www.ncbi.nlm.nih.gov/pubmed/22280021
http://dx.doi.org/10.1021/bi201722j

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