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Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics

Allostery offers a highly specific way to modulate protein function. Therefore, understanding this mechanism is of increasing interest for protein science and drug discovery. However, allosteric signal transmission is difficult to detect experimentally and to model because it is often mediated by lo...

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Detalles Bibliográficos
Autores principales: Pandini, Alessandro, Fornili, Arianna, Fraternali, Franca, Kleinjung, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290435/
https://www.ncbi.nlm.nih.gov/pubmed/22071506
http://dx.doi.org/10.1096/fj.11-190868