Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Members of protein families often share conserved structural subsites for interaction with chemically similar moieties despite low sequence identity. We propose a core site-moiety map of multiple proteins (called CoreSiMMap) to discover inhibitors and mechanisms by profiling subsite-moiety interacti...

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Detalles Bibliográficos
Autores principales: Hsu, Kai-Cheng, Cheng, Wen-Chi, Chen, Yen-Fu, Wang, Hung-Jung, Li, Ling-Ting, Wang, Wen-Ching, Yang, Jinn-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://www.ncbi.nlm.nih.gov/pubmed/22393385
http://dx.doi.org/10.1371/journal.pone.0032142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290551/
https://www.ncbi.nlm.nih.gov/pubmed/22393385
http://dx.doi.org/10.1371/journal.pone.0032142

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