Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

Here we show that bortezomib induces effective proteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma (DLBCL) cells. This leads to induction of endoplasmic reticulum (ER) stress as demonstrated by accumulation of the protein CHOP, as well as autophagy,...

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Detalles Bibliográficos
Autores principales: Jia, Li, Gopinathan, Ganga, Sukumar, Johanna T., Gribben, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290566/
https://www.ncbi.nlm.nih.gov/pubmed/22393418
http://dx.doi.org/10.1371/journal.pone.0032584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290566/
https://www.ncbi.nlm.nih.gov/pubmed/22393418
http://dx.doi.org/10.1371/journal.pone.0032584

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