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Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

Here we show that bortezomib induces effective proteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma (DLBCL) cells. This leads to induction of endoplasmic reticulum (ER) stress as demonstrated by accumulation of the protein CHOP, as well as autophagy,...

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Detalles Bibliográficos
Autores principales:	Jia, Li, Gopinathan, Ganga, Sukumar, Johanna T., Gribben, John G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290566/ https://www.ncbi.nlm.nih.gov/pubmed/22393418 http://dx.doi.org/10.1371/journal.pone.0032584

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