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Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition
The transforming growth factor-β (TGF-β) signaling pathway is often misregulated during cancer progression. In early stages of tumorigenesis, TGF-β acts as a tumor suppressor by inhibiting proliferation and inducing apoptosis. However, as the disease progresses, TGF-β switches to promote tumorigenic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290638/ https://www.ncbi.nlm.nih.gov/pubmed/22238361 http://dx.doi.org/10.1091/mbc.E11-06-0537 |