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Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine

Outward currents through Kir2.1 channels play crucial roles in controlling the electrical properties of excitable cells, and such currents are subjected to voltage-dependent block by intracellular Mg(2+) and polyamines that bind to both high- and low-affinity sites on the channels. Under physiologic...

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Detalles Bibliográficos
Autores principales: Liu, Tai-An, Chang, Hsueh-Kai, Shieh, Ru-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290795/
https://www.ncbi.nlm.nih.gov/pubmed/22371365
http://dx.doi.org/10.1085/jgp.201110736