Cell-mediated Protection in Influenza Infection
Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291410/ https://www.ncbi.nlm.nih.gov/pubmed/16494717 http://dx.doi.org/10.3201/eid1201.051237 |
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author | Thomas, Paul G. Keating, Rachael Hulse-Post, Diane J. Doherty, Peter C. |
author_facet | Thomas, Paul G. Keating, Rachael Hulse-Post, Diane J. Doherty, Peter C. |
author_sort | Thomas, Paul G. |
collection | PubMed |
description | Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell–mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure. |
format | Online Article Text |
id | pubmed-3291410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-32914102012-03-05 Cell-mediated Protection in Influenza Infection Thomas, Paul G. Keating, Rachael Hulse-Post, Diane J. Doherty, Peter C. Emerg Infect Dis Perspective Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell–mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure. Centers for Disease Control and Prevention 2006-01 /pmc/articles/PMC3291410/ /pubmed/16494717 http://dx.doi.org/10.3201/eid1201.051237 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Perspective Thomas, Paul G. Keating, Rachael Hulse-Post, Diane J. Doherty, Peter C. Cell-mediated Protection in Influenza Infection |
title | Cell-mediated Protection in Influenza Infection |
title_full | Cell-mediated Protection in Influenza Infection |
title_fullStr | Cell-mediated Protection in Influenza Infection |
title_full_unstemmed | Cell-mediated Protection in Influenza Infection |
title_short | Cell-mediated Protection in Influenza Infection |
title_sort | cell-mediated protection in influenza infection |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291410/ https://www.ncbi.nlm.nih.gov/pubmed/16494717 http://dx.doi.org/10.3201/eid1201.051237 |
work_keys_str_mv | AT thomaspaulg cellmediatedprotectionininfluenzainfection AT keatingrachael cellmediatedprotectionininfluenzainfection AT hulsepostdianej cellmediatedprotectionininfluenzainfection AT dohertypeterc cellmediatedprotectionininfluenzainfection |