Cell-mediated Protection in Influenza Infection

Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from is...

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Autores principales: Thomas, Paul G., Keating, Rachael, Hulse-Post, Diane J., Doherty, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291410/
https://www.ncbi.nlm.nih.gov/pubmed/16494717
http://dx.doi.org/10.3201/eid1201.051237
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author Thomas, Paul G.
Keating, Rachael
Hulse-Post, Diane J.
Doherty, Peter C.
author_facet Thomas, Paul G.
Keating, Rachael
Hulse-Post, Diane J.
Doherty, Peter C.
author_sort Thomas, Paul G.
collection PubMed
description Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell–mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure.
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spelling pubmed-32914102012-03-05 Cell-mediated Protection in Influenza Infection Thomas, Paul G. Keating, Rachael Hulse-Post, Diane J. Doherty, Peter C. Emerg Infect Dis Perspective Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the role of CD4+ and CD8+ T cell–mediated immunity in influenza infection and the available data on the role of these responses in protection from highly pathogenic influenza infection. We discuss the advantages of developing a vaccine based on cell-mediated immune responses toward highly pathogenic influenza virus and potential problems arising from immune pressure. Centers for Disease Control and Prevention 2006-01 /pmc/articles/PMC3291410/ /pubmed/16494717 http://dx.doi.org/10.3201/eid1201.051237 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Perspective
Thomas, Paul G.
Keating, Rachael
Hulse-Post, Diane J.
Doherty, Peter C.
Cell-mediated Protection in Influenza Infection
title Cell-mediated Protection in Influenza Infection
title_full Cell-mediated Protection in Influenza Infection
title_fullStr Cell-mediated Protection in Influenza Infection
title_full_unstemmed Cell-mediated Protection in Influenza Infection
title_short Cell-mediated Protection in Influenza Infection
title_sort cell-mediated protection in influenza infection
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291410/
https://www.ncbi.nlm.nih.gov/pubmed/16494717
http://dx.doi.org/10.3201/eid1201.051237
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