Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged

We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibilit...

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Detalles Bibliográficos
Autores principales: Verma, Deeptak, Jacobs, Donald J., Livesay, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291535/
https://www.ncbi.nlm.nih.gov/pubmed/22396637
http://dx.doi.org/10.1371/journal.pcbi.1002409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291535/
https://www.ncbi.nlm.nih.gov/pubmed/22396637
http://dx.doi.org/10.1371/journal.pcbi.1002409

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