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Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged
We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibilit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291535/ https://www.ncbi.nlm.nih.gov/pubmed/22396637 http://dx.doi.org/10.1371/journal.pcbi.1002409 |