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Degenerate T-cell Recognition of Peptides on MHC Molecules Creates Large Holes in the T-cell Repertoire

The cellular immune system screens peptides presented by host cells on MHC molecules to assess if the cells are infected. In this study we examined whether the presented peptides contain enough information for a proper self/nonself assessment by comparing the presented human (self) and bacterial or...

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Detalles Bibliográficos
Autores principales: Calis, Jorg J. A., de Boer, Rob J., Keşmir, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291541/
https://www.ncbi.nlm.nih.gov/pubmed/22396638
http://dx.doi.org/10.1371/journal.pcbi.1002412