DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress

Nijmegen Breakage Syndrome (NBS), an autosomal recessive genetic instability syndrome, is caused by hypomorphic mutation of the NBN gene, which codes for the protein nibrin. Nibrin is an integral member of the MRE11/RAD50/NBN (MRN) complex essential for processing DNA double-strand breaks. Cardinal...

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Detalles Bibliográficos
Autores principales: Krenzlin, Harald, Demuth, Ilja, Salewsky, Bastian, Wessendorf, Petra, Weidele, Kathrin, Bürkle, Alexander, Digweed, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291567/
https://www.ncbi.nlm.nih.gov/pubmed/22396666
http://dx.doi.org/10.1371/journal.pgen.1002557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291567/
https://www.ncbi.nlm.nih.gov/pubmed/22396666
http://dx.doi.org/10.1371/journal.pgen.1002557

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