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Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila
Altered function of Cdk5 kinase is associated with many forms of neurodegenerative disease in humans. We show here that inactivating the Drosophila Cdk5 ortholog, by mutation of its activating subunit, p35, causes adult-onset neurodegeneration in the fly. In the mutants, a vacuolar neuropathology is...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291642/ https://www.ncbi.nlm.nih.gov/pubmed/22228754 http://dx.doi.org/10.1242/dmm.008847 |