Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS both result from altered function of the hERG channel. We...

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Detalles Bibliográficos
Autores principales: Lahti, Anna L., Kujala, Ville J., Chapman, Hugh, Koivisto, Ari-Pekka, Pekkanen-Mattila, Mari, Kerkelä, Erja, Hyttinen, Jari, Kontula, Kimmo, Swan, Heikki, Conklin, Bruce R., Yamanaka, Shinya, Silvennoinen, Olli, Aalto-Setälä, Katriina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291643/
https://www.ncbi.nlm.nih.gov/pubmed/22052944
http://dx.doi.org/10.1242/dmm.008409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291643/
https://www.ncbi.nlm.nih.gov/pubmed/22052944
http://dx.doi.org/10.1242/dmm.008409

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