Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

Lipid droplet formation and subsequent steatosis (the abnormal retention of lipids within a cell) has been reported to contribute to hepatotoxicity and is an adverse effect of many pharmacological agents including the antiepileptic drug valproic acid (VPA). In this study, we have developed a simple...

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Detalles Bibliográficos
Autores principales: Elphick, Lucy M., Pawolleck, Nadine, Guschina, Irina A., Chaieb, Leila, Eikel, Daniel, Nau, Heinz, Harwood, John L., Plant, Nick J., Williams, Robin S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291644/
https://www.ncbi.nlm.nih.gov/pubmed/22003123
http://dx.doi.org/10.1242/dmm.008391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291644/
https://www.ncbi.nlm.nih.gov/pubmed/22003123
http://dx.doi.org/10.1242/dmm.008391

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