Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma

PTEN is an essential tumor suppressor that antagonizes Akt/PKB signaling. The zebrafish genome encodes two Pten genes, ptena and ptenb. Here, we report that zebrafish mutants that retain a single wild-type copy of ptena or ptenb (ptena(+/−)ptenb(−/−) or ptena(−/−)ptenb(+/−)) are viable and fertile....

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Detalles Bibliográficos
Autores principales: Choorapoikayil, Suma, Kuiper, Raoul V., de Bruin, Alain, den Hertog, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291645/
https://www.ncbi.nlm.nih.gov/pubmed/22071262
http://dx.doi.org/10.1242/dmm.008326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291645/
https://www.ncbi.nlm.nih.gov/pubmed/22071262
http://dx.doi.org/10.1242/dmm.008326

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