Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations

Inhibition of p53-MDM2/MDMX interaction is considered to be a promising strategy for anticancer drug design to activate wild-type p53 in tumors. We carry out molecular dynamics (MD) simulations to study the binding mechanisms of peptide and non-peptide inhibitors to MDM2/MDMX. The rank of binding fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jianzhong, Zhang, Dinglin, Zhang, Yuxin, Li, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292015/
https://www.ncbi.nlm.nih.gov/pubmed/22408446
http://dx.doi.org/10.3390/ijms13022176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292015/
https://www.ncbi.nlm.nih.gov/pubmed/22408446
http://dx.doi.org/10.3390/ijms13022176

Ejemplares similares