Pyrrolo[3,2-d]pyrimidine Derivatives as Type II Kinase Insert Domain Receptor (KDR) Inhibitors: CoMFA and CoMSIA Studies

Kinase insert domain receptor (KDR) inhibitors have been proved to be very effective anticancer agents. Molecular docking, 3D-QSAR methods, CoMFA and CoMSIA were performed on pyrrolo[3,2-d]pyrimidine derivatives as non-ATP competitive KDR inhibitors (type II). The bioactive conformation was explored...

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Detalles Bibliográficos
Autores principales: Wu, Xiao-Yun, Chen, Wen-Hua, Wu, Shu-Guang, Tian, Yuan-Xin, Zhang, Jia-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292029/
https://www.ncbi.nlm.nih.gov/pubmed/22408460
http://dx.doi.org/10.3390/ijms13022387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292029/
https://www.ncbi.nlm.nih.gov/pubmed/22408460
http://dx.doi.org/10.3390/ijms13022387

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