Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

BACKGROUND: Indirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery syst...

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Detalles Bibliográficos
Autores principales: Chen, Zhi-Qiang, Liu, Ying, Zhao, Ji-Hui, Wang, Lan, Feng, Nian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292421/
https://www.ncbi.nlm.nih.gov/pubmed/22403491
http://dx.doi.org/10.2147/IJN.S28761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292421/
https://www.ncbi.nlm.nih.gov/pubmed/22403491
http://dx.doi.org/10.2147/IJN.S28761

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