Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 Å resolution...

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Detalles Bibliográficos
Autores principales: Huang, Weijiao, Choi, Wooyoung, Hu, Wanqiu, Mi, Na, Guo, Qiang, Ma, Meisheng, Liu, Mei, Tian, Yuan, Lu, Peilong, Wang, Feng-Liang, Deng, Haiteng, Liu, Lei, Gao, Ning, Yu, Li, Shi, Yigong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292424/
https://www.ncbi.nlm.nih.gov/pubmed/22310240
http://dx.doi.org/10.1038/cr.2012.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292424/
https://www.ncbi.nlm.nih.gov/pubmed/22310240
http://dx.doi.org/10.1038/cr.2012.24

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