Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding the HERG channel. Several LQT2-associated mutations have been mapped to the amino terminal cytoplasmic Per-Arnt-Sim (PAS) domain of the HERG1a channel subunit. Here we have characterized the trafficking properties o...

Descripción completa

Detalles Bibliográficos
Autores principales: Harley, Carol A., Jesus, Catarina S. H., Carvalho, Ricardo, Brito, Rui M. M., Morais-Cabral, João H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292575/
https://www.ncbi.nlm.nih.gov/pubmed/22396785
http://dx.doi.org/10.1371/journal.pone.0032654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292575/
https://www.ncbi.nlm.nih.gov/pubmed/22396785
http://dx.doi.org/10.1371/journal.pone.0032654

Ejemplares similares