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Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel

Inherited human long-QT2 syndrome (LQTS) results from mutations in the gene encoding the HERG channel. Several LQT2-associated mutations have been mapped to the amino terminal cytoplasmic Per-Arnt-Sim (PAS) domain of the HERG1a channel subunit. Here we have characterized the trafficking properties o...

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Detalles Bibliográficos
Autores principales:	Harley, Carol A., Jesus, Catarina S. H., Carvalho, Ricardo, Brito, Rui M. M., Morais-Cabral, João H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292575/ https://www.ncbi.nlm.nih.gov/pubmed/22396785 http://dx.doi.org/10.1371/journal.pone.0032654

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