Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process. Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible loss of division potential of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Hewitt, Graeme, Jurk, Diana, Marques, Francisco D.M., Correia-Melo, Clara, Hardy, Timothy, Gackowska, Agata, Anderson, Rhys, Taschuk, Morgan, Mann, Jelena, Passos, João F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292717/
https://www.ncbi.nlm.nih.gov/pubmed/22426229
http://dx.doi.org/10.1038/ncomms1708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292717/
https://www.ncbi.nlm.nih.gov/pubmed/22426229
http://dx.doi.org/10.1038/ncomms1708

Ejemplares similares