Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels

BACKGROUND: Imiquimod (IQ) is known as an agonist of Toll-like receptor 7 (TLR7) and is widely used to treat various infectious skin diseases. However, it causes severe itching sensation as its side effect. The precise mechanism of how IQ causes itching sensation is unknown. A recent report suggeste...

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Detalles Bibliográficos
Autores principales: Lee, Jaekwang, Kim, Taekeun, Hong, Jinpyo, Woo, Junsung, Min, Hyunjung, Hwang, Eunmi, Lee, Sung Joong, Lee, C Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292985/
https://www.ncbi.nlm.nih.gov/pubmed/22233604
http://dx.doi.org/10.1186/1744-8069-8-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292985/
https://www.ncbi.nlm.nih.gov/pubmed/22233604
http://dx.doi.org/10.1186/1744-8069-8-2

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