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Selection of recombinant MVA by rescue of the essential D4R gene
Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant...
Autores principales: | Ricci, Patricia S, Schäfer, Birgit, Kreil, Thomas R, Falkner, Falko G, Holzer, Georg W |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293099/ https://www.ncbi.nlm.nih.gov/pubmed/22152060 http://dx.doi.org/10.1186/1743-422X-8-529 |
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