The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment

G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice lacking GRK6 (GRK6-KO mice). To understand how GRK6 modulates the behaviora...

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Detalles Bibliográficos
Autores principales: Managò, Francesca, Espinoza, Stefano, Salahpour, Ali, Sotnikova, Tatyana D., Caron, Marc G., Premont, Richard T., Gainetdinov, Raul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293148/
https://www.ncbi.nlm.nih.gov/pubmed/22393477
http://dx.doi.org/10.1038/srep00301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293148/
https://www.ncbi.nlm.nih.gov/pubmed/22393477
http://dx.doi.org/10.1038/srep00301

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