Synthesis by Ring-Closing Metathesis and Cytotoxic Evaluation of Novel Thienylmacrolactones

This paper describes the synthesis and biological evaluation of macrolactones containing a thienyl substituent as simple analogues of epothilones. The compounds were prepared in a brief and efficient manner from thiophene-2-carbaldehyde using a ring-closing metathesis with Grubbs I or Grubbs II cata...

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Detalles Bibliográficos
Autores principales: Krauss, Jürgen, Köbler, Daniela, Miller, Verena, Bracher, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293355/
https://www.ncbi.nlm.nih.gov/pubmed/22396902
http://dx.doi.org/10.3797/scipharm.1109-09

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293355/
https://www.ncbi.nlm.nih.gov/pubmed/22396902
http://dx.doi.org/10.3797/scipharm.1109-09

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