An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid

Wnt/β-catenin signalling controls development and tissue homeostasis. Moreover, activated β-catenin can be oncogenic and, notably, drives colorectal cancer. Inhibiting oncogenic β-catenin has proven a formidable challenge. Here we design a screen for small-molecule inhibitors of β-catenin's bin...

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Detalles Bibliográficos
Autores principales: de la Roche, Marc, Rutherford, Trevor J., Gupta, Deepti, Veprintsev, Dmitry B., Saxty, Barbara, Freund, Stefan M., Bienz, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293410/
https://www.ncbi.nlm.nih.gov/pubmed/22353711
http://dx.doi.org/10.1038/ncomms1680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293410/
https://www.ncbi.nlm.nih.gov/pubmed/22353711
http://dx.doi.org/10.1038/ncomms1680

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