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Reactive Oxygen Species Suppress Cardiac Na(V)1.5 Expression through Foxo1
Na(V)1.5 is a cardiac voltage-gated Na(+) channel αsubunit and is encoded by the SCN5a gene. The activity of this channel determines cardiac depolarization and electrical conduction. Channel defects, including mutations and decrease of channel protein levels, have been linked to the development of c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293505/ https://www.ncbi.nlm.nih.gov/pubmed/22400069 http://dx.doi.org/10.1371/journal.pone.0032738 |