Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4(+) T-cell repertoire selection

Human CD4(+) αβ T cells are activated via T-cell receptor recognition of peptide epitopes presented by major histocompatibility complex (MHC) class II (MHC-II). The open ends of the MHC-II binding groove allow peptide epitopes to extend beyond a central nonamer core region at both the amino- and car...

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Detalles Bibliográficos
Autores principales: Cole, David K., Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James P., Wynn, Katherine K., Gostick, Emma, Sewell, Andrew K., Gallimore, Awen M., Ladell, Kristin, Price, David A., Gougeon, Marie-Lise, Godkin, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293629/
https://www.ncbi.nlm.nih.gov/pubmed/22314361
http://dx.doi.org/10.1038/ncomms1665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293629/
https://www.ncbi.nlm.nih.gov/pubmed/22314361
http://dx.doi.org/10.1038/ncomms1665

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