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Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels

The cell cycle is a temporal program that regulates DNA synthesis and cell division. When we compared the codon usage of cell cycle-regulated genes with that of other genes, we discovered that there is a significant preference for non-optimal codons. Moreover, genes encoding proteins that cycle at t...

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Detalles Bibliográficos
Autores principales: Frenkel-Morgenstern, Milana, Danon, Tamar, Christian, Thomas, Igarashi, Takao, Cohen, Lydia, Hou, Ya-Ming, Jensen, Lars Juhl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293633/
https://www.ncbi.nlm.nih.gov/pubmed/22373820
http://dx.doi.org/10.1038/msb.2012.3