Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

BACKGROUND: MicroRNA (miRNA) target genes tend to have relatively long and conserved 3' untranslated regions (UTRs), but to what degree these characteristics contribute to miRNA targeting is poorly understood. Different high-throughput experiments have, for example, shown that miRNAs preferenti...

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Detalles Bibliográficos
Autores principales: Saito, Takaya, Sætrom, Pål
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293725/
https://www.ncbi.nlm.nih.gov/pubmed/22325809
http://dx.doi.org/10.1186/1758-907X-3-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293725/
https://www.ncbi.nlm.nih.gov/pubmed/22325809
http://dx.doi.org/10.1186/1758-907X-3-3

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