Diphenyl Urea Derivatives as Inhibitors of Transketolase: A Structure-Based Virtual Screening

Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold, found by applying structure-based virtual sc...

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Detalles Bibliográficos
Autores principales: Obiol-Pardo, Cristian, Alcarraz-Vizán, Gema, Cascante, Marta, Rubio-Martinez, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293897/
https://www.ncbi.nlm.nih.gov/pubmed/22403640
http://dx.doi.org/10.1371/journal.pone.0032276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293897/
https://www.ncbi.nlm.nih.gov/pubmed/22403640
http://dx.doi.org/10.1371/journal.pone.0032276

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