Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein

A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−)β2m(−/−) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(−/−) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−) (DP4) mouse. We confi...

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Detalles Bibliográficos
Autores principales: Ru, Zhitao, Xiao, Wenjun, Pajot, Anthony, Kou, Zhihua, Sun, Shihui, Maillere, Bernard, Zhao, Guangyu, Ojcius, David M., Lone, Yu-chun, Zhou, Yusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293898/
https://www.ncbi.nlm.nih.gov/pubmed/22403638
http://dx.doi.org/10.1371/journal.pone.0032247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293898/
https://www.ncbi.nlm.nih.gov/pubmed/22403638
http://dx.doi.org/10.1371/journal.pone.0032247

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