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Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein
A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−)β2m(−/−) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(−/−) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−) (DP4) mouse. We confi...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293898/ https://www.ncbi.nlm.nih.gov/pubmed/22403638 http://dx.doi.org/10.1371/journal.pone.0032247 |