Interaction Pattern of Arg 62 in the A-Pocket of Differentially Disease-Associated HLA-B27 Subtypes Suggests Distinct TCR Binding Modes

The single amino acid replacement Asp116His distinguishes the two subtypes HLA-B*2705 and HLA-B*2709 which are, respectively, associated and non-associated with Ankylosing Spondylitis, an autoimmune chronic inflammatory disease. The reason for this differential association is so far poorly understoo...

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Detalles Bibliográficos
Autores principales: Nurzia, Elisa, Narzi, Daniele, Cauli, Alberto, Mathieu, Alessandro, Tedeschi, Valentina, Caristi, Silvana, Sorrentino, Rosa, Böckmann, Rainer A., Fiorillo, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293911/
https://www.ncbi.nlm.nih.gov/pubmed/22403718
http://dx.doi.org/10.1371/journal.pone.0032865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293911/
https://www.ncbi.nlm.nih.gov/pubmed/22403718
http://dx.doi.org/10.1371/journal.pone.0032865

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