Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer

Wnt7a is known to be a tumor suppressor that is lost in NSCLC, but no mechanism of loss has been established. Methylation of promoter regions has been established as a common mechanism of loss of tumor suppressor expression in NSCLC. We previously demonstrated that loss of Wnt7a in non-transformed l...

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Detalles Bibliográficos
Autores principales: Tennis, Meredith A., VanScoyk, Michelle M., Wilson, Lora A., Kelley, Nicole, Winn, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293913/
https://www.ncbi.nlm.nih.gov/pubmed/22403725
http://dx.doi.org/10.1371/journal.pone.0032921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293913/
https://www.ncbi.nlm.nih.gov/pubmed/22403725
http://dx.doi.org/10.1371/journal.pone.0032921

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