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Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)–calcineurin–NFAT signaling
In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type Ca(2+) channels, and couples Ca(2+) influx to activation of calcineurin and of its substrate, the transcription factor NFAT. Here we show that an IAIIIT anchoring site in human AKAP79 binds the same su...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294036/ https://www.ncbi.nlm.nih.gov/pubmed/22343722 http://dx.doi.org/10.1038/nsmb.2238 |