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USF Binding Sequences from the HS4 Insulator Element Impose Early Replication Timing on a Vertebrate Replicator
The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating. GC-rich regions are gene dense and are enriched for active transcription, suggesting a connection between gene...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295818/ https://www.ncbi.nlm.nih.gov/pubmed/22412349 http://dx.doi.org/10.1371/journal.pbio.1001277 |