Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

AIMS/HYPOTHESIS: Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size. MET...

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Detalles Bibliográficos
Autores principales: Fava, E., Dehghany, J., Ouwendijk, J., Müller, A., Niederlein, A., Verkade, P., Meyer-Hermann, M., Solimena, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296007/
https://www.ncbi.nlm.nih.gov/pubmed/22252472
http://dx.doi.org/10.1007/s00125-011-2438-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296007/
https://www.ncbi.nlm.nih.gov/pubmed/22252472
http://dx.doi.org/10.1007/s00125-011-2438-4

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