Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Background. Hypercholesterolemia and disruptions of the blood brain barrier (BBB) have been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease (AD). Simvastatin therapy may be of benefit in treating AD; however, its mechanism has not been yet fully understood. Object...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Xijuan, Guo, Maojuan, Su, Jinling, Lu, Bin, Ma, Dongming, Zhang, Ruifeng, Yang, Lin, Wang, Qiang, Ma, Yiwen, Fan, Yingchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296225/
https://www.ncbi.nlm.nih.gov/pubmed/22506129
http://dx.doi.org/10.1155/2012/109324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296225/
https://www.ncbi.nlm.nih.gov/pubmed/22506129
http://dx.doi.org/10.1155/2012/109324

Ejemplares similares