Cargando…

A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease

Alzheimer's disease (AD) is characterised by the aggregation of two quite different proteins, namely, amyloid-beta (Aβ), which forms extracellular plaques, and tau, the main component of cytoplasmic neurofibrillary tangles. The amyloid hypothesis proposes that Aβ plaques precede tangle formatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Proctor, Carole J., Gray, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296276/ https://www.ncbi.nlm.nih.gov/pubmed/22482080 http://dx.doi.org/10.1155/2012/978742

Ejemplares similares

GSK3 and p53 - is there a link in Alzheimer's disease?
por: Proctor, Carole J, et al.
Publicado: (2010)

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
por: Arnsten, Amy F. T., et al.
Publicado: (2020)

Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology
por: Funk, Kristen E., et al.
Publicado: (2012)

Unifying Hypothesis of Dopamine Neuron Loss in Neurodegenerative Diseases: Focusing on Alzheimer's Disease
por: Krashia, Paraskevi, et al.
Publicado: (2019)

Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer’s Disease
por: Kaeser, Gwendolyn E., et al.
Publicado: (2020)

Investigating Interventions in Alzheimer's Disease with Computer Simulation Models
por: Proctor, Carole J., et al.
Publicado: (2013)

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging
por: Glennon, Elizabeth B. C., et al.
Publicado: (2013)

Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease
por: Lu, Kirsty, et al.
Publicado: (2021)

The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence
por: Kosenko, Elena, et al.
Publicado: (2020)

The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease
por: Sandebring, Anna, et al.
Publicado: (2013)

Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease
por: Kalaria, Rajesh N., et al.
Publicado: (2021)

From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis
por: Grünblatt, Edna, et al.
Publicado: (2023)

Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer’s disease
por: Rodríguez, J. J., et al.
Publicado: (2023)

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease
por: Twohig, Daniel, et al.
Publicado: (2018)

Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer's Disease
por: Van Dooren, Tom, et al.
Publicado: (2014)

The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago
por: Snow, Alan David, et al.
Publicado: (2021)

Transcriptomic profiling of sporadic Alzheimer’s disease patients
por: Caldwell, Andrew B., et al.
Publicado: (2022)

A unifying hypothesis for pathogenesis and prevention of necrotizing enterocolitis
por: Kosloske, Ann M.
Publicado: (1990)

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
por: Israel, Mason A., et al.
Publicado: (2012)

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease
por: Craddock, Travis J. A., et al.
Publicado: (2012)

Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease
por: Skov, Jeppe, et al.
Publicado: (2014)

Lipofuscin Hypothesis of Alzheimer's Disease
por: Giaccone, Giorgio, et al.
Publicado: (2011)

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection
por: Henao‐Restrepo, Julián, et al.
Publicado: (2022)

Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease
por: Sandebring, Anna, et al.
Publicado: (2013)

Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease
por: Sandebring, Anna, et al.
Publicado: (2013)

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease
por: Condello, Carlo, et al.
Publicado: (2018)

The linear model and hypothesis: a general unifying theory
por: Seber, George
Publicado: (2015)

The neural crest cell hypothesis: no unified explanation for domestication
por: Johnsson, Martin, et al.
Publicado: (2021)

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
por: Kametani, Fuyuki, et al.
Publicado: (2018)

Infectious hypothesis of Alzheimer disease
por: Seaks, Charles E., et al.
Publicado: (2020)

Sleep apnea awakens cancer: A unifying immunological hypothesis
por: Gozal, David, et al.
Publicado: (2014)

Endothelial dysfunction: a unifying hypothesis for the burden of cardiovascular diseases in sub-Saharan Africa
por: Sampson, Uchechukwu KA, et al.
Publicado: (2015)

Functional gradients of the medial parietal cortex in a healthy cohort with family history of sporadic Alzheimer’s disease
por: Veréb, Dániel, et al.
Publicado: (2023)

Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease
por: Martín-Maestro, Patricia, et al.
Publicado: (2017)

Characterization of the initial complaint and care pathways prior to diagnosis in very young sporadic Alzheimer’s disease
por: Olivieri, Pauline, et al.
Publicado: (2021)

A Comprehensive Machine Learning Framework for the Exact Prediction of the Age of Onset in Familial and Sporadic Alzheimer’s Disease
por: Vélez, Jorge I., et al.
Publicado: (2021)

Explaining oscillations and variability in the p53-Mdm2 system
por: Proctor, Carole J, et al.
Publicado: (2008)

A Hypnic Hypothesis of Alzheimer's Disease
por: Clark, Camilla N., et al.
Publicado: (2013)

Brain Amyloid in Sporadic Young Onset Alzheimer’s Disease
por: Panegyres, Peter K., et al.
Publicado: (2023)

Characterization of Familial and Sporadic Migraine
por: Ravn, Julie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d5lmd38a9orqddv1jvjsf3n35h