Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese Rats

BACKGROUND AND AIMS: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby incr...

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Detalles Bibliográficos
Autores principales: de Lartigue, Guillaume, Barbier de la Serre, Claire, Espero, Elvis, Lee, Jennifer, Raybould, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296757/
https://www.ncbi.nlm.nih.gov/pubmed/22412960
http://dx.doi.org/10.1371/journal.pone.0032967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296757/
https://www.ncbi.nlm.nih.gov/pubmed/22412960
http://dx.doi.org/10.1371/journal.pone.0032967

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