Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Considerable data support the idea that Foxo1 drives the liver transcriptional program during fasting and is inhibited by Akt after feeding. Mice with hepatic deletion of Akt1 and Akt2 were glucose intolerant, insulin resistant, and defective in the transcriptional response to feeding in liver. Thes...

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Detalles Bibliográficos
Autores principales: Lu, Mingjian, Wan, Min, Leavens, Karla F., Chu, Qingwei, Monks, Bobby R., Fernandez, Sully, Ahima, Rexford S., Ueki, Kohjiro, Kahn, C. Ronald, Birnbaum, Morris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296881/
https://www.ncbi.nlm.nih.gov/pubmed/22344295
http://dx.doi.org/10.1038/nm.2686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296881/
https://www.ncbi.nlm.nih.gov/pubmed/22344295
http://dx.doi.org/10.1038/nm.2686

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