Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress

Following DNA damage, cells display complex multi-pathway signaling dynamics that connect cell-cycle arrest and DNA repair in G1, S, or G2/M phase with phenotypic fate decisions made between survival, cell-cycle re-entry and proliferation, permanent cell-cycle arrest, or cell death. How these phenot...

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Detalles Bibliográficos
Autores principales: Tentner, Andrea R, Lee, Michael J, Ostheimer, Gerry J, Samson, Leona D, Lauffenburger, Douglas A, Yaffe, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296916/
https://www.ncbi.nlm.nih.gov/pubmed/22294094
http://dx.doi.org/10.1038/msb.2012.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296916/
https://www.ncbi.nlm.nih.gov/pubmed/22294094
http://dx.doi.org/10.1038/msb.2012.1

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