Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor

[Image: see text] A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report additional str...

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Detalles Bibliográficos
Autores principales: Dockendorff, Chris, Aisiku, Omozuanvbo, VerPlank, Lynn, Dilks, James R., Smith, Daniel A., Gunnink, Susanna F., Dowal, Louisa, Negri, Joseph, Palmer, Michelle, MacPherson, Lawrence, Schreiber, Stuart L., Flaumenhaft, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297361/
https://www.ncbi.nlm.nih.gov/pubmed/22408714
http://dx.doi.org/10.1021/ml2002696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297361/
https://www.ncbi.nlm.nih.gov/pubmed/22408714
http://dx.doi.org/10.1021/ml2002696

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