Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

[Image: see text] Prostaglandins (PGs) are powerful lipid mediators in many physiological and pathophysiological responses. They are produced by oxidation of arachidonic acid (AA) by cyclooxygenases (COX-1 and COX-2) followed by metabolism of endoperoxide intermediates by terminal PG synthases. PG b...

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Detalles Bibliográficos
Autores principales: Liedtke, Andy J., Crews, Brenda C., Daniel, Cristina M., Blobaum, Anna L., Kingsley, Philip J., Ghebreselasie, Kebreab, Marnett, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297362/
https://www.ncbi.nlm.nih.gov/pubmed/22263894
http://dx.doi.org/10.1021/jm201528b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297362/
https://www.ncbi.nlm.nih.gov/pubmed/22263894
http://dx.doi.org/10.1021/jm201528b

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